Article
W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity.
Nature - 26 Jan 1995
Huizinga J D, Thuneberg L, Klüppel M, Malysz J, Mikkelsen H B, Bernstein A
Abstract excerpt
The pacemaker activity in the mammalian gut is responsible for generating anally propagating phasic contractions. The cellular basis for this intrinsic activity is unknown. The smooth muscle cells of the external muscle layers and the innervated cellular network of interstitial cells of Cajal, which is closely associated with the external muscle layers of the mammalian gut, have both been proposed to stimulate...
Topics
- Action Potentials
- Animals
- Connective Tissue
- Female
- Intestine, Small
- Methylene Blue
- Mice
- Muscle, Smooth
- Mutation
- Myenteric Plexus
- Neurons
- Peristalsis