Article
Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice.
Archives of histology and cytology - 1 Oct 2007
Iino Satoshi, Horiguchi Satomi, Horiguchi Kazuhide, Nojyo Yoshiaki
Abstract excerpt
Interstitial cells of Cajal (ICC) are important regulatory cells generating electrical rhythmicity and transducing neural signals in the gastrointestinal musculature. ICC express the proto-oncogene c-kit, a receptor tyrosine kinase, and can be examined morphologically using the c-Kit antibody. The c-kit gene is allelic with the murine white-spotting locus W, and the c-kit mutation (W mutation) affects various...
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