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Article

Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.

The Journal of physiology - 1 Oct 1994

Ward S M, Burns A J, Torihashi S, Sanders K M

Abstract excerpt

1. Interstitial cells of Cajal (ICs) have been proposed as pacemakers in the gastrointestinal tract. We studied the characteristics and distribution of ICs and electrical activity of small intestinal muscles from mice with mutations at the dominant-white spotting/c-kit (W) locus because the tyrosine kinase function of c-kit may be important in the development of the IC network. 2. W/WV mutants (days 3-30...

Topics

Animals
Electric Stimulation
Electrophysiology
Immunohistochemistry
In Vitro Techniques
Intestines
Membrane Potentials
Methylene Blue
Mice
Mice, Inbred C57BL
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myenteric Plexus

Protein-Tyrosine Kinases

Proto-Oncogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 7853230
DOI: 10.1113/jphysiol.1994.sp020343
PMCID: PMC1155780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7853230-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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