Article
Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment.
Intervirology - 1 Jan 2012
Akuta Norio, Suzuki Fumitaka, Hirakawa Miharu, Kawamura Yusuke, Yatsuji Hiromi, Sezaki Hitomi, Suzuki Yoshiyuki, Hosaka Tetsuya, Kobayashi Masahiro, Kobayashi Mariko, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Chayama Kazuaki, Nakamura Yusuke, Kumada Hiromitsu
Abstract excerpt
OBJECTIVES: Genetic variation near the IL28B gene and substitution of aa 70 and 91 in the core region of HCV-1b are useful as predictors of treatment efficacy to telaprevir/pegylated interferon (PEG-IFN)/ribavirin, but its impact on viral dynamics is not clear. METHODS: This study investigated predictive factors of viral dynamics during 12- or 24-week regimen of triple therapy in 80 Japanese adults infected with...
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