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Article

Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin.

Journal of medical virology - 1 Mar 2011

Inoue Yuko, Hiramatsu Naoki, Oze Tsugiko, Yakushijin Takayuki, Mochizuki Kiyoshi, Fukuda Kazuto, Mita Eiji, Haruna Yoshimichi, Inoue Atsuo, Imai Yasuharu, Hosui Atsushi, Miyagi Takuya, Yoshida Yuichi, Tatsumi Tomohide, Kiso Shinichi, Kanto Tatsuya, Kasahara Akinori, Takehara Tetsuo, Hayashi Norio

Abstract excerpt

Previous reports demonstrated that amino acid (aa) substitutions in the hepatitis C virus (HCV) core protein are predictors of non-virological responses to pegylated interferon (Peg-IFN) and ribavirin combination therapy. The aim of this study was to investigate the impact of core aa substitutions on viral kinetics during the treatment and relapse after the treatment. The 187 patients with HCV genotype 1 enrolled...

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PMID: 21264862
DOI: 10.1002/jmv.21975

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