Article
Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.
International journal of oncology - 1 Jun 2009
Kawamata Norihiko, Ogawa Seishi, Seeger Karl, Kirschner-Schwabe Renate, Huynh Thien, Chen John, Megrabian Nairi, Harbott Jochen, Zimmermann Martin, Henze Günter, Schrappe Martin, Bartram Claus R, Koeffler H Phillip
Abstract excerpt
Acute lymphoblastic leukemia (ALL) cells at relapse are frequently more resistant to treatment than primary clones and this may be caused by further genetic changes in the ALL cells at relapse. These acquired genomic abnormalities have not been fully characterized. To examine the additional genomic alterations of ALL at relapse, we performed single nucleotide polymorphism genomic microarry (SNP-chip) analysis on...
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