Article
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray.
Blood - 15 Jan 2008
Kawamata Norihiko, Ogawa Seishi, Zimmermann Martin, Kato Motohiro, Sanada Masashi, Hemminki Kari, Yamatomo Go, Nannya Yasuhito, Koehler Rolf, Flohr Thomas, Miller Carl W, Harbott Jochen, Ludwig Wolf-Dieter, Stanulla Martin, Schrappe Martin, Bartram Claus R, Koeffler H Phillip
Abstract excerpt
Pediatric acute lymphoblastic leukemia (ALL) is a malignant disease resulting from accumulation of genetic alterations. A robust technology, single nucleotide polymorphism oligonucleotide genomic microarray (SNP-chip) in concert with bioinformatics offers the opportunity to discover the genetic lesions associated with ALL. We examined 399 pediatric ALL samples and their matched remission marrows at 50,000/250,000...
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