Article
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo.
PLoS genetics - 1 May 2009
Ribeyre Cyril, Lopes Judith, Boulé Jean-Baptiste, Piazza Aurèle, Guédin Aurore, Zakian Virginia A, Mergny Jean-Louis, Nicolas Alain
Abstract excerpt
In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood. Here, we provide evidence for a new Pif1 function by demonstrating that its absence promotes genetic instability of alleles of the G-rich human minisatellite CEB1 inserted in the Saccharomyces cerevisiae genome, but not of other tandem...
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