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Article

Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury.

Journal of the American Society of Nephrology : JASN - 1 Jul 2004

Wang Zhaohui, Zahedi Kamyar, Barone Sharon, Tehrani Kathy, Rabb Hamid, Matlin Karl, Casero Robert A, Soleimani Manoocher

Abstract excerpt

To ascertain the role of spermidine/spermine N-1-acetyl-transferase (SSAT; the rate-limiting enzyme in polyamine catabolism) in cell injury, cultured kidney (HEK 293) cells conditionally overexpressing SSAT were generated. The SSAT expression was induced and its enzymatic activity increased 24 h after addition of tetracycline and remained elevated over the length of the experiments. Induction of SSAT upregulated...

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Identifiers

PMID: 15213272
DOI: 10.1097/01.asn.0000131525.77636.d5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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