Article

Histone methyltransferase SET8 aggravates acute kidney injury through activation of p53 and downregulation of PTEN

2023-09-21

Abstract excerpt

<title>Abstract</title> <p>SET8 is a histone H4 lysine 20 methyltransferase (H4K20) that regulates transcriptional and posttranslational modifications and is related to tumorigenesis and other diseases. Its role in acute kidney injury (AKI) remains unexplored. In this study, we investigated the role and underlying mechanism of SET8 in a murine model of cisplatin-induced AKI and apoptosis of cultured murine proxim...

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Literature Corpus work: 51cc2f75-565d-5297-990c-c0a9a7f65327
DOI: 10.21203/rs.3.rs-3303812/v1

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