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Article

MicroRNA-709 Mediates Acute Tubular Injury through Effects on Mitochondrial Function

17 Oct 2017

Abstract excerpt

Export Mitochondrial dysfunction has important roles in the pathogenesis of AKI, yet therapeutic approaches to improve mitochondrial function remain limited. In this study, we investigated the pathogenic role of microRNA-709 (miR-709) in mediating mitochondrial impairment and tubular cell death in AKI. In a cisplatin-induced AKI mouse model and in biopsy samples of human AKI kidney tissue, miR-709 was...

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PMID: 29042455
DOI: 10.1681/asn.2017040381

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