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Article

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jun 2009

Zoeller Jason J, Whitelock John M, Iozzo Renato V

Abstract excerpt

Using the zebrafish, we previously identified a central function for perlecan during angiogenic blood vessel development. Here, we explored the nature of perlecan function during developmental angiogenesis. A close examination of individual endothelial cell behavior revealed that perlecan is required for proper endothelial cell migration and proliferation. Because these events are largely mediated by VEGF-VEGFR2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19422911
DOI: 10.1016/j.matbio.2009.04.010
PMCID: PMC2705690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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