Article
Angiomotin regulates endothelial cell migration during embryonic angiogenesis.
Genes & development - 15 Aug 2007
Aase Karin, Ernkvist Mira, Ebarasi Lwaki, Jakobsson Lars, Majumdar Arindam, Yi Chunling, Birot Olivier, Ming Yue, Kvanta Anders, Edholm Dan, Aspenström Pontus, Kissil Joseph, Claesson-Welsh Lena, Shimono Akihiko, Holmgren Lars
Abstract excerpt
The development of the embryonic vascular system into a highly ordered network requires precise control over the migration and branching of endothelial cells (ECs). We have previously identified angiomotin (Amot) as a receptor for the angiogenesis inhibitor angiostatin. Furthermore, DNA vaccination targeting Amot inhibits angiogenesis and tumor growth. However, little is known regarding the role of Amot in...
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