Article
Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.
Developmental cell - 23 Jan 2017
De Angelis Jessica E, Lagendijk Anne K, Chen Huijun, Tromp Alisha, Bower Neil I, Tunny Kathryn A, Brooks Andrew J, Bakkers Jeroen, Francois Mathias, Yap Alpha S, Simons Cas, Wicking Carol, Hogan Benjamin M, Smith Kelly A
Abstract excerpt
Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular matrix (ECM), but the complexity of ECM control of VEGF signaling and angiogenesis remains far...
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