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Perlecan and Tumor Angiogenesis

1 Nov 2003

Abstract excerpt

Perlecan is a major heparan sulfate proteoglycan (HSPG) of basement membranes (BMs) and connective tissues. The core protein of perlecan is divided into five domains based on sequence homology to other known proteins. Commonly, the N-terminal domain I of mammalian perlecan is substituted with three HS chains that can bind a number of matrix molecules, cytokines, and growth factors. Perlecan is essential for...

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PMID: 14566013
DOI: 10.1177/002215540305101101

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