Article

Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights

2022-01-05

Abstract excerpt

<h4>ABSTRACT</h4> The wasabi receptor, TRPA1, is a non-selective homotetrameric cation channel expressed in primary sensory neurons of the pain pathway, where it is activated by diverse chemical irritants. A direct role for TRPA1 in human health has been highlighted by the discovery of genetic variants associated with severe pain disorders. One such TRPA1 mutant was identified in a father-son pair with cramp fasc...

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Literature Corpus work: 874c3a0f-6181-5d2b-9399-246de2a2a749
DOI: 10.1101/2022.01.05.475133

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