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Article

Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb.

Developmental biology - 15 Jul 2009

Lallemand Yvan, Bensoussan Vardina, Cloment Cécile Saint, Robert Benoît

Abstract excerpt

In tetrapods, the anteroposterior (AP) patterning of the limb is under the control of the antagonistic activities of the secreted factor Sonic hedgehog (Shh) and Gli3R, the truncated repressor form of the transcription factor Gli3. In this report, we show that Msx1 and Msx2 are targets and downstream effectors of Gli3R. Consequently, in Shh null mutants, Msx genes are overexpressed and, furthermore, partially...

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Source

Identifiers

PMID: 19422820
DOI: 10.1016/j.ydbio.2009.04.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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