Article
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.
Physiological genomics - 4 Oct 2004
Michalkiewicz Mieczyslaw, Michalkiewicz Teresa, Ettinger Ruth A, Rutledge Elizabeth A, Fuller Jessica M, Moralejo Daniel H, Van Yserloo Brian, MacMurray Armand J, Kwitek Anne E, Jacob Howard J, Lander Eric S, Lernmark Ake
Abstract excerpt
A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional importance of this novel gene. A 150-kb P1 artificial chromosome (PAC) transgene harboring a...
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