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Article

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.

Physiological genomics - 3 Mar 2010

Moralejo Daniel H, Hansen Carl T, Treuting Piper, Hessner Martin J, Fuller Jessica M, Van Yserloo Brian, Jensen Richard, Osborne William, Kwitek Anne E, Lernmark Ake

Abstract excerpt

Rodents homozygous for autosomal leptin receptor gene mutations not only become obese, insulin resistant, and hyperleptinemic but also develop a dysregulated immune system. Using marker-assisted breeding to introgress the Koletsky rat leptin receptor mutant (lepr-/lepr-), we developed a novel congenic BBDR.(lepr-/lepr-) rat line to study the development of obesity and type 2 diabetes (T2D) in the BioBreeding (BB)...

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Identifiers

PMID: 19996157
DOI: 10.1152/physiolgenomics.00186.2009
PMCID: PMC2841494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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