Article
Klotho variants and chronic hemodialysis mortality.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2009
Friedman David J, Afkarian Maryam, Tamez Hector, Bhan Ishir, Isakova Tamara, Wolf Myles, Ankers Elizabeth, Ye Jun, Tonelli Marcello, Zoccali Carmine, Kuro-o Makoto, Moe Orson, Karumanchi S Ananth, Thadhani Ravi
Abstract excerpt
Patients with end-stage renal disease (ESRD) suffer exceptionally high mortality rates in their first year of chronic hemodialysis. Both vitamin D and fibroblast growth factor (FGF)-23 levels correlate with survival in these patients. Klotho is a protein in the vitamin D/FGF-23 signaling pathway that has been linked with accelerated aging and early mortality in animal models. We therefore hypothesized that...
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