Article
Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African Americans.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Oct 2010
Bostrom Meredith A, Hicks Pamela J, Lu Lingyi, Langefeld Carl D, Freedman Barry I, Bowden Donald W
Abstract excerpt
BACKGROUND: Non-diabetic forms of nephropathy commonly lead to end-stage renal disease (non-DM ESRD). Previous studies have demonstrated that African Americans are more susceptible to non-DM ESRD compared to other ethnic groups, and this risk has a strong genetic component. A genome-wide scan for ESRD in African American families enriched for non-DM ESRD showed evidence for linkage in chromosome 13q33.3, and a...
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