Article
Klotho gene polymorphisms associated with bone density of aged postmenopausal women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2002
Kawano Ken-ichi, Ogata Naoshi, Chiano Mathias, Molloy Helen, Kleyn Patrick, Spector Tim D, Uchida Motoyuki, Hosoi Takayuki, Suzuki Takao, Orimo Hajime, Inoue Satoshi, Nabeshima Yoichi, Nakamura Kozo, Kuro-o Makoto, Kawaguchi Hiroshi
Abstract excerpt
Because mice deficient in klotho gene expression exhibit multiple aging phenotypes including osteopenia, we explored the possibility that the klotho gene may contribute to age-related bone loss in humans by examining the association between klotho gene polymorphisms and bone density in two genetically distinct racial populations: the white and the Japanese. Screening of single-nucleotide polymorphisms (SNPs) in...
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