Article
Roles of the Drosophila NudE protein in kinetochore function and centrosome migration.
Journal of cell science - 1 Jun 2009
Wainman Alan, Creque Jacklyn, Williams Byron, Williams Erika V, Bonaccorsi Silvia, Gatti Maurizio, Goldberg Michael L
Abstract excerpt
We examined the distribution of the dynein-associated protein NudE in Drosophila larval brain neuroblasts and spermatocytes, and analyzed the phenotypic consequences of a nudE null mutation. NudE can associate with kinetochores, spindles and the nuclear envelope. In nudE mutant brain mitotic cells, centrosomes are often detached from the poles. Moreover, the centrosomes of mutant primary spermatocytes do not...
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