Article
Mutations in INSL3 and RXFP2 genes in cryptorchid boys.
Annals of the New York Academy of Sciences - 1 Apr 2009
Ferlin Alberto, Zuccarello Daniela, Garolla Andrea, Selice Riccardo, Vinanzi Cinzia, Ganz Francesco, Zanon Gian Franco, Zuccarello Biagio, Foresta Carlo
Abstract excerpt
Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects. We found five RXFP2 mutations in five bilateral cryptorchid boys, one INSL3 mutation in a unilateral cryptorchid boy, and one INSL3 mutation in a...
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