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Article

Role of INSL3 and LGR8 in cryptorchidism and testicular functions.

Reproductive biomedicine online - 1 Sept 2004

Foresta Carlo, Ferlin Alberto

Abstract excerpt

Cryptorchidism is the most frequent congenital anomaly of the urogenital tract in human males. INSL3 and LGR8/GREAT proteins seem to act as ligand and receptor respectively, and to have a role in gubernaculum development involved in testicular descent. Mutations in the INSL3 gene or LGR8/GREAT were found to be associated with cryptorchidism in humans. In a cohort of 135 ex-cryptorchid patients and 100 controls,...

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Source

Identifiers

PMID: 15353080
DOI: 10.1016/s1472-6483(10)62144-x

Genes

INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role of INSL3 and LGR8 in cryptorchidism and testicular functions.PMID 15353080Read ↗

The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.Semantic proximity Read ↗

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GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

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The molecular basis of cryptorchidism.Semantic proximity Read ↗

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Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism.Semantic proximity Read ↗

Role of Hormones, Genes, and Environment in Human CryptorchidismSemantic proximity Read ↗

Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism.Semantic proximity Read ↗

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