Article
Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism.
Molecular human reproduction - 1 Apr 2000
Krausz C, Quintana-Murci L, Fellous M, Siffroi J P, McElreavey K
Abstract excerpt
The aetiology of cryptorchidism is for the most part unknown and appears to be multifactorial. Recently, a product of Leydig cells termed Leydig insulin-like hormone (INSL3) has been proposed as a putative trophic hormone of the first part of descent. Absence of Insl3 in male mice results in bilateral cryptorchidism and mutations involving this gene may be a cause of cryptorchidism in man. We sequenced both exons...
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