Article
The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.
The Journal of clinical endocrinology and metabolism - 1 Sept 2003
Ferlin Alberto, Simonato Mauro, Bartoloni Lucia, Rizzo Giorgia, Bettella Andrea, Dottorini Tania, Dallapiccola Bruno, Foresta Carlo
Abstract excerpt
Testicular descent is a complex multistep embryonic process requiring the interaction between anatomical and hormonal factors. Failure in any of these steps results in cryptorchidism, the most frequent congenital anomaly of the urogenital tract in human males. Evidence for a genetic cause for cryptorchidism is numerous and supported by animal models. In particular, INSL3 and LGR8/GREAT proteins seem to act as...
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