Article
Novel mutations involving the INSL3 gene associated with cryptorchidism.
The Journal of urology - 1 May 2007
El Houate Brahim, Rouba Hassan, Sibai Hicham, Barakat Abdelhamid, Chafik Abdelaziz, Chadli El Bekkay, Imken Laila, Bogatcheva Natalia V, Feng Shu, Agoulnik Alexander I, McElreavey Ken
Abstract excerpt
PURPOSE: Cryptorchidism affects 1% to 9% of full-term male neonates. Hypospadias is the second most frequent congenital anomaly seen in newborn males. These pathological conditions are part of the testicular dysgenesis syndrome. Insulin-like factor 3 and LGR8 (leucine-rich repeat-containing G protein-coupled receptor 8), acting as a hormone and a receptor, respectively, are involved in control of the first phase...
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