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Article

INSL3/RXFP2 Signaling in Testicular Descent

1 Apr 2009

Abstract excerpt

Mutations of the insulin-like peptide 3 (INSL3) hormone or its receptor, RXFP2, cause intraabdominal cryptorchidism in male mice. Specific RXFP2 expression in mouse gubernacula was detected at embryonic day 14.5 and markedly increased after birth in the developing cremaster muscle, as well as in the epididymis and testicular Leydig and germ cells. INSL3 treatment stimulated cell proliferation of embryonic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19416188
DOI: 10.1111/j.1749-6632.2009.03841.x

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INSL3/RXFP2 Signaling in Testicular DescentPMID 19416188Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs1Semantic proximity Read ↗

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1Semantic proximity Read ↗

Cryptorchidism in mice mutant for Insl3.Semantic proximity Read ↗

Familial bilateral cryptorchidism is caused by recessive variants in RXFP2Semantic proximity Read ↗

Insulin‐like 3 signalling in testicular descentSemantic proximity Read ↗

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.Semantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.Semantic proximity Read ↗

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling.Semantic proximity Read ↗

Bi-allelic variants inINSL3andRXFP2cause bilateral cryptorchidism and male infertilitySemantic proximity Read ↗

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