Article
Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism.
Reproductive biomedicine online - 1 Jan 2000
Roh Jaesook, Virtanen Helena, Kumagai Jin, Sudo Satoko, Kaleva Marko, Toppari Jorma, Hsueh Aaron J W
Abstract excerpt
Cryptorchidism is the most frequent congenital anomaly of the urogenital tract in the male. Although in Western countries 1-2% of males at the age of 3 months are diagnosed with this condition, its aetiology is still unknown. Animal models suggest a possible genetic basis for this disorder. Recently, the INSL3 (Leydig insulin-like peptide) gene and its cognate receptor, LGR8, were found to be important in...
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