Article
Genetic alterations associated with cryptorchidism.
JAMA - 19 Nov 2008
Ferlin Alberto, Zuccarello Daniela, Zuccarello Biagio, Chirico Maria Rosaria, Zanon Giovanni Franco, Foresta Carlo
Abstract excerpt
CONTEXT: Cryptorchidism is the most frequent congenital birth defect in male children and represents an important risk factor for infertility and testicular cancer. Major regulators of testicular descent are the hormones insulin-like factor 3 (INSL3) and testosterone, and disruption of these pathways might cause cryptorchidism. OBJECTIVE: To determine the frequency of genetic alterations in cryptorchidism. DESIGN...
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