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Article

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

Pharmacogenetics and genomics - 1 May 2009

Ufer Mike, Mosyagin Igor, Muhle Hiltrud, Jacobsen Thies, Haenisch Sierk, Häsler Robert, Faltraco Frank, Remmler Cornelia, von Spiczak Sarah, Kroemer Heyo K, Runge Uwe, Boor Rainer, Stephani Ulrich, Cascorbi Ingolf

Abstract excerpt

OBJECTIVE: We aimed to evaluate the association of non-response to antiepileptic pharmacotherapy with the frequency of variant alleles in the drug transporter genes ABCB1 and ABCC2 or in the CYP2C locus in young patients with epilepsy and an independent cohort of adults with drug-refractory epilepsy. METHODS: A total of 221 pediatric or adolescent Caucasian patients with epilepsy (105 females; age: 14.5+/-6.54...

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Share to Anticonvulsants
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Epilepsy

Share to Epistasis, Genetic

Share to Multidrug Resistance-Associated Protein 2

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Source

Identifiers

PMID: 19415824
DOI: 10.1097/fpc.0b013e328329940b

Genes

ABCC2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.PMID 19415824Read ↗

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