Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered expression of the human base excision repair gene NTH1 in gastric cancer.

Carcinogenesis - 1 Aug 2009

Goto Masanori, Shinmura Kazuya, Igarashi Hisaki, Kobayashi Minatsu, Konno Hiroyuki, Yamada Hidetaka, Iwaizumi Moriya, Kageyama Shinji, Tsuneyoshi Toshihiro, Tsugane Shoichiro, Sugimura Haruhiko

Abstract excerpt

A base excision repair enzyme, NTH1, has activity that is capable of removing oxidized pyrimidines, such as thymine glycol (Tg), from DNA. To clarify whether the NTH1 gene is involved in gastric carcinogenesis, we first examined the NTH1 expression level in eight gastric cancer cell lines, and the results showed that NTH1 expression was downregulated in all of them, including cell line AGS. Next, a comparison of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonuclease (Pyrimidine Dimer)
Share to Gastric Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Intestinal Neoplasms

Share to Luciferases

Share to Polymorphism, Single-Stranded Conformational

Share to Stomach Neoplasms

Share to Thymine

Source

Identifiers

PMID: 19414504
DOI: 10.1093/carcin/bgp108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered expression of the human base excision repair gene NTH1 in gastric cancer.PMID 19414504Read ↗

Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.Semantic proximity Read ↗

NTHL1 in genomic integrity, aging and cancer.Semantic proximity Read ↗

Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.Semantic proximity Read ↗

The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.Semantic proximity Read ↗

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation.Semantic proximity Read ↗

Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme.Semantic proximity Read ↗

Novel mutations of OGG1 base excision repair pathway gene in laryngeal cancer patients.Semantic proximity Read ↗

Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cellsSemantic proximity Read ↗

DNA Base-Excision Repair Genes OGG1 and NTH1 in Brazilian Lung Cancer Patients.Semantic proximity Read ↗

Clinical significance of expression and epigenetic profiling ofTUSC1in gastric cancerSemantic proximity Read ↗

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.Semantic proximity Read ↗

DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.