Article
DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.
Molecular biology reports - 1 Nov 2011
Engin Ayse Basak, Karahalil Bensu, Engin Atilla, Karakaya Ali Esat
Abstract excerpt
Although the developmental stages of gastric carcinoma are still not clear, the constantly generated reactive oxygen and nitrogen species (ROS/RNS) may contribute to the process of carcinogenesis by interacting with DNA. 8-oxoguanine DNA glycosylase-1 (OGG1) is an enzyme involved in base excision repair of 8-oxoguanine that is one of the premutagenic lesions generated by ROS in DNA. The bulky adducts, are...
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