Article
Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation.
Proceedings of the National Academy of Sciences of the United States of America - 27 Aug 2013
Galick Heather A, Kathe Scott, Liu Minmin, Robey-Bond Susan, Kidane Dawit, Wallace Susan S, Sweasy Joann B
Abstract excerpt
Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed by DNA N-glycosylases. One of these, n(th) endonuclease III-like (NTH1), removes oxidized pyrimidines from DNA,...
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