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Article

Novel mutations of OGG1 base excision repair pathway gene in laryngeal cancer patients.

Familial cancer - 1 Dec 2012

Mahjabeen Ishrat, Masood Nosheen, Baig Ruqia Mehmood, Sabir Maimoona, Inayat Uzma, Malik Faraz Arshad, Kayani Mahmood Akhtar

Abstract excerpt

OGG1 (The human 8-oxoguanine glycosylase 1) is the primary enzyme in BER (base excision repair) pathway, responsible for the excision of 7, 8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct that occurs as a result of exposure to reactive oxygen species. OGG1 gene is highly polymorphic among humans and is mutated in cancer cells. In this case control study, all exons of OGG1 gene and its exon/intron...

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Identifiers

PMID: 22829015
DOI: 10.1007/s10689-012-9554-2

Genes

OGG1

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