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Article

Clinical significance of expression and epigenetic profiling ofTUSC1in gastric cancer

2 Apr 2014

Abstract excerpt

BACKGROUND AND OBJECTIVES: The prognosis of advanced gastric cancer (GC) remains dismal. The aim of this study was to identify a novel tumor suppressor gene (TSG) with repressed transcription by aberrant DNA methylation in GC. METHODS: The expression and methylation status of tumor suppressor candidate 1 (TUSC1) were evaluated in GC cell lines and 112 pairs of surgical specimens. TUSC1 protein expression and...

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PMID: 24700496
DOI: 10.1002/jso.23614

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