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Article

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease.

Mechanisms of ageing and development - 1 Jan 2000

Ross Owen A, Gosal David, Stone Jeremy T, Lincoln Sarah J, Heckman Michael G, Irvine G Brent, Johnston Janet A, Gibson J Mark, Farrer Matthew J, Lynch Timothy

Abstract excerpt

Genetic variation of the alpha-synuclein gene (SNCA) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease (PD) remains elusive. The present study identifies an association of common SNCA polymorphisms with disease susceptibility in a series of Irish PD patients. There is evidence for association with alternate regions, of protection and risk which may act...

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Source

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Identifiers

PMID: 17531291
DOI: 10.1016/j.mad.2007.04.002
PMCID: PMC2970620

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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