Article
Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.
PloS one - 1 Jan 2009
Li Ge, Peskind Elaine R, Millard Steven P, Chi Peter, Sokal Izabela, Yu Chang-En, Bekris Lynn M, Raskind Murray A, Galasko Douglas R, Montine Thomas J
Abstract excerpt
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline. METHODOLOGY/PRINCIPAL FINDINGS, AND CONCLUSIONS/SIGNIFICANCE: CSF concentration of BDNF, Abeta(42) and total tau were...
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