Article

Brain-Derived Neurotrophic Factor: the Link Between Amyloid-β and Memory Loss

2011-08-25

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory. Brain BDNF levels correlate with cognitive status. BDNF is downregulated in Alzheimer’s disease, in age-related cognitive impairment and in a variety of other neurodegenerative and psychiatric disorders exhibiting cognitive deficits. BDNF is downregulated in the Alzheimer’s disease brain by soluble, aggregated amyloid-β, actin...

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Literature Corpus work: fb32b37f-091e-5473-86f2-23064f826174
DOI: 10.2217/fnl.11.44

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