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Article

Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study.

JAMA neurology - 1 Jan 2014

Weinstein Galit, Beiser Alexa S, Choi Seung Hoan, Preis Sarah R, Chen Tai C, Vorgas Demetrios, Au Rhoda, Pikula Aleksandra, Wolf Philip A, DeStefano Anita L, Vasan Ramachandran S, Seshadri Sudha

Abstract excerpt

IMPORTANCE: In animal studies, brain-derived neurotrophic factor (BDNF) has been shown to impact neuronal survival and function and improve synaptic plasticity and long-term memory. Circulating BDNF levels increase with physical activity and caloric restriction, thus BDNF may mediate some of the observed associations between lifestyle and the risk for dementia. Some prior studies showed lower circulating BDNF in...

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Identifiers

PMID: 24276217
DOI: 10.1001/jamaneurol.2013.4781
PMCID: PMC4056186

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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