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Article

Decreased Neurotrophic Support is Associated with Cognitive Decline in Non-Demented Subjects.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Forlenza Orestes Vicente, Miranda Aline Silva, Guimar Izabela, Talib Leda Leme, Diniz Breno Satler, Gattaz Wagner Farid, Teixeira Antonio Lucio

Abstract excerpt

BACKGROUND: There is evidence of decreased neurotrophic support in Alzheimer's disease (AD), including its prodromal stages, but it is not clear whether this abnormality represents a marker of this process. OBJECTIVE: To determine serum concentrations of a panel of neurotrophic factors (BDNF, NGF, and GDNF) in a cross-section of elderly patients with mild cognitive impairment (MCI) and AD compared to cognitively...

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Source

Identifiers

PMID: 25737042
DOI: 10.3233/JAD-150172

Genes

BDNF
NGF
GDNF
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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