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Article

Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220.

Biochemical and biophysical research communications - 3 Jul 2009

Son You Lee, Lee Young Chul

Abstract excerpt

Dimerization-induced activation of LXR is a unique allosteric mechanism described only for LXR/RXR heterodimers. Previously, we demonstrated that RXR functions as an allosteric activator of LXR binding to ASC-2 coactivator rather than as a direct interaction partner. Here, we investigated the molecular basis of the interaction between LXR/RXR and TRAP220 fragment (TN1/2) harboring two NR boxes. We found that...

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Source

Identifiers

PMID: 19410560
DOI: 10.1016/j.bbrc.2009.04.131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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