Article
Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain.
Molecular cell - 12 Mar 2004
Acevedo Mari Luz, Lee Kathleen C, Stender Joshua D, Katzenellenbogen Benita S, Kraus W Lee
Abstract excerpt
How nuclear receptors (NRs) coordinate the sequential, ligand-dependent recruitment of multiple coactivator complexes (e.g., SRC complexes and Mediator) that share similar receptor binding determinants is unclear. We show that although the receptor binding subunits of these complexes (i.e., SRCs and Med220, respectively) share overlapping binding sites on estrogen receptor alpha (ERalpha), information contained...
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