Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization.

Molecular genetics and metabolism - 1 Jan 2000

Iyer Anita K, Zhang Yao-Hua, McCabe Edward R B

Abstract excerpt

Small heterodimer partner (SHP; NR0B2) is an unusual orphan member of the nuclear receptor superfamily that functions as a corepressor of other nuclear receptors through heterodimeric interactions. Mutations in SHP are associated with mild obesity and insulin resistance. The protein domain structure of SHP is similar to Dosage-sensitive sex reversal adrenal hypoplasia congenita (AHC) critical region on the X...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Cytoplasm
Share to DAX-1 Orphan Nuclear Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Immunoprecipitation

Share to Peptide Fragments

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Retinoic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 17686645
DOI: 10.1016/j.ymgme.2007.06.009
PMCID: PMC2065763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization.PMID 17686645Read ↗

Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP HeterodimersSemantic proximity Read ↗

DAX1: Increasing complexity in the roles of this novel nuclear receptor.Semantic proximity Read ↗

DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual DifferentiationSemantic proximity Read ↗

NR0B1A: an alternatively spliced form of NR0B1.Semantic proximity Read ↗

DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.Semantic proximity Read ↗

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA.Semantic proximity Read ↗

Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1.Semantic proximity Read ↗

Late-onset X-linked adrenal hypoplasia (DAX-1, NR0B1): two new adult-onset cases from a single center.Semantic proximity Read ↗

Role of DAX-1 (NR0B1) and steroidogenic factor-1 (NR5A1) in human adrenal function.Semantic proximity Read ↗

The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian ReproductionSemantic proximity Read ↗

Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.Semantic proximity Read ↗

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.