Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand- and coactivator-mediated transactivation function (AF2) of the androgen receptor ligand-binding domain is inhibited by the cognate hinge region.

The Journal of biological chemistry - 9 Mar 2001

Wang Q, Lu J, Yong E L

Abstract excerpt

Transactivation functions (AF2) in the ligand-binding domains (LBD) of many steroid receptors are well characterized, but there is little evidence to support such a function for the LBD of the androgen receptor (AR). We report a mutant AR, with residues 628-646 in the hinge region deleted, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Immunoblotting
Share to Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-fos

Share to Proto-Oncogene Proteins c-jun

Share to Receptors, Androgen

Share to Transcription Factor AP-1

Share to Transcriptional Activation

Source

Identifiers

PMID: 11102454
DOI: 10.1074/jbc.M009916200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11102454-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ligand- and coactivator-mediated transactivation function (AF2) of the androgen receptor ligand-binding domain is inhibited by the cognate hinge region.PMID 11102454Read ↗

The Hinge Region Regulates DNA Binding, Nuclear Translocation, and Transactivation of the Androgen ReceptorSemantic proximity Read ↗

Specific properties of a C-terminal truncated androgen receptor detected in hormone refractory prostate cancer.Semantic proximity Read ↗

Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate.Semantic proximity Read ↗

Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif.Semantic proximity Read ↗

Diverse roles of androgen receptor (AR) domains in AR-mediated signalingSemantic proximity Read ↗

Identification of a highly conserved domain in the androgen receptor that suppresses the DNA-binding domain-DNA interactions.Semantic proximity Read ↗

Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.Semantic proximity Read ↗

Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2).Semantic proximity Read ↗

Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor.Semantic proximity Read ↗

Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain.Semantic proximity Read ↗

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifenSemantic proximity Read ↗

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.