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Article

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2018

Gallego-Bartolomé Javier, Gardiner Jason, Liu Wanlu, Papikian Ashot, Ghoshal Basudev, Kuo Hsuan Yu, Zhao Jenny Miao-Chi, Segal David J, Jacobsen Steven E

Abstract excerpt

DNA methylation is an important epigenetic modification involved in gene regulation and transposable element silencing. Changes in DNA methylation can be heritable and, thus, can lead to the formation of stable epialleles. A well-characterized example of a stable epiallele in plants is fwa, which consists of the loss of DNA cytosine methylation (5mC) in the promoter of the FLOWERING WAGENINGEN (FWA) gene, causing...

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Identifiers

PMID: 29444862
DOI: 10.1073/pnas.1716945115
PMCID: PMC5834696

Genes

TET1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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