<i>E2F1</i> Expression Is Deregulated and Plays an Oncogenic Role in Sporadic Burkitt's Lymphoma

Abstract excerpt

Current treatments of sporadic Burkitt's lymphoma (sBL) are associated with severe toxicities. A better understanding of sBL formation would facilitate development of less toxic therapies. The etiology of sBL remains, however, largely unknown, C-MYC up-regulation being the only lesion known to occur in all sBL cases. Several studies examining the role of C-MYC in the pathogenesis of BL have concluded that C-MYC...

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