Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ- <i>Myc</i> Lymphoma by Restoring Oncogene-Induced Senescence

15 Dec 2012

Abstract excerpt

UNLABELLED: MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in Eμ-Myc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell lymphoproliferative disorders. Deregulated expression of MYC results in increased mTOR complex 1 (mTORC1) signaling. As tumors with mTORC1 activation are sensitive to mTORC1 inhibition, we used everolimus, a potent and specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to PI3K/AKT/mTOR signaling in cancer
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23242809
DOI: 10.1158/2159-8290.cd-12-0404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ- <i>Myc</i> Lymphoma by Restoring Oncogene-Induced SenescencePMID 23242809Read ↗

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.Semantic proximity Read ↗

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemiaSemantic proximity Read ↗

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancerSemantic proximity Read ↗

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesisSemantic proximity Read ↗

<scp>AKT</scp> signalling is required for ribosomal <scp>RNA</scp> synthesis and progression of <scp>E</scp>μ‐<i>Myc </i><scp>B</scp>‐cell lymphoma <i>in vivo</i>Semantic proximity Read ↗

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.Semantic proximity Read ↗

Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies.Semantic proximity Read ↗

mTORC1 promotes survival through translational control of Mcl-1Semantic proximity Read ↗

Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1Semantic proximity Read ↗

Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary EpitheliumSemantic proximity Read ↗

Phosphorylation of AKT and ERK1/2 and mutations of PIK3CA and PTEN are predictive of breast cancer cell sensitivity to everolimus in vitro.Semantic proximity Read ↗

Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.