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Article

Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1999

Reinke V, Bortner D M, Amelse L L, Lundgren K, Rosenberg M P, Finlay C A, Lozano G

Abstract excerpt

Expression of a beta-lactoglobulin (BLG)/mdm2 transgene (BLGmdm2) in the epithelial cells of the mouse mammary gland causes an uncoupling of S phase from M phase, resulting in polyploidy and tumor formation. The cell cycle defects are independent of interactions with p53. Because MDM2 also binds and activates the S phase-specific transcription factor E2F1, we hypothesized that increased E2F1 activity causes the...

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Identifiers

PMID: 10099828

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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